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Evidence that Obstructive Sleep Apnea Causes Brain Damage

Brain damage may explain problems related to sleep apnea such as memory loss and mood changes.


American Academy of Sleep Medicine
AASM | 03/26/2009

Studies show that obstructive sleep apnea (OSA) affects much more than just your sleep. It can even damage your brain.
A recent brain imaging study from France involved 16 adults. Each of them had just been diagnosed with sleep apnea.
In numerous brain regions the study found a loss of “gray matter”. This is brain tissue that contains fibers and nerve cell bodies. There also was a decrease in brain metabolism.
The authors suggest that these changes may explain some of the impairments that often occur in people with sleep apnea. Examples include attention lapses and memory loss. The study was published in the March 2009 issue of the Journal of Sleep Research.
The results are similar to those found by a research team from UCLA. Their study was published in Neuroscience Letters in June 2008.
They reported that people with sleep apnea have tissue loss in the “mammillary bodies.” These are brain regions that help store memory.
In July 2008 the UCLA team published another brain imaging study in the journal Sleep. It involved 41 people with moderate to severe sleep apnea. It also included 69 control subjects matched by age.
Results show that people with sleep apnea have extensive alterations in “white matter.” This is nerve tissue in the brain. It contains fibers that are insulated with myelin - a white, fatty sheath. 
The structural changes appear in brain regions that help control mood and memory. These regions also play a role in adjusting your blood pressure. Damage also was found in fiber pathways that connect these brain regions.
What causes the brain damage? The authors suggest that oxygen, blood flow and blood pressure may be involved.
Sleep apnea involves breathing pauses that can occur hundreds of times during a night of sleep. These pauses can produce drastic changes in oxygen levels. 
These breathing pauses also reduce blood flow in the brain. People with sleep apnea also are at risk for high blood pressure. Both of these conditions create a potential for brain tissue damage.
Dr. Ronald Harper of UCLA said that the studies show how important it is for sleep apnea to be treated. CPAP is the most common treatment for sleep apnea.
“The findings make it all the more imperative that OSA be treated as soon as possible to prevent further injury,” Harper told the AASM. “The long-term effects of OSA are terribly damaging to memory and thinking processes.”
Can treatment reverse the brain damage caused by sleep apnea? The authors are uncertain if the changes are permanent.
But studies show that CPAP does help your heart. It may even save your life.

 

Study: Sleep Apnea Masks Help Hearts Heal, Too

Main Category: Sleep / Sleep Disorders / Insomnia
Also Included In: Cardiovascular / Cardiology;  Heart Disease
Article Date: 05 Feb 2009 - 2:00 PST

It's estimated that some 12 million Americans suffer from sleep apnea*- which means they could stop breathing in their sleep, in some cases hundreds of times per night. Most people who have moderate to severe cases of sleep apnea are given a mask to wear at night that helps them sleep better, but it might be doing much more than that. In the first study of it's kind, Doctors have found it may be helping to heal the heart too.
It may look uncomfortable, but Lou Flocken says this mask is helping him get the best sleep of his life. After years of snoring, his wife insisted he go to the doctor who diagnosed Lou with sleep apnea.
"They said that I had 35 interruptions of my sleep per hour. So that meant that I was never getting fully asleep," says Lou.
Because he was deprived of oxygen at night, Lou's heart was being damaged, which is why he started using a continuous positive airway pressure mask, or a C-PAP mask. Doctors have known for sometime that it helps patients breathe better.
"What we haven't known as well, is, whether or not C-PAP benefits the heart," says Doctor Subha Raman, MD at the Ohio State University Medical Center.
So doctors at the Ohio State University Medical Center decided to find out. They took MRI's of patients to get a good idea of the size and shape of their hearts when they were first diagnosed. Then patients were given C-PAP masks to sleep in. After several weeks they came back for another MRI, and doctors were surprised by what they saw.
"We saw that before treatment, the heart was enlarged. But after three months of careful use of their CPAP, we saw a reduction in the enlargement of the heart," says Dr. Raman.
In all, experts say of the 13 patients who tried it, there were "significant" changes in the right ventricle of the heart.* Which means this mask not only helps with sleep disorders, but may be helping doctors get to the heart of a much more serious problem, as well.
Doctors say if left untreated, sleep apnea can lead to high blood pressure, and increase your risk of
diabetes or having a stroke. If someone complains that you snore loudly and often you may want to get checked out by your doctor.
 

Link Between Obesity And Dangerous Sleep Apnea In Truck Drivers

Main Category: Obesity / Weight Loss / Fitness
Also Included In: Sleep / Sleep Disorders / Insomnia;  Public Health
Article Date: 12 Mar 2009 - 1:00 PDT

Truck crashes are a significant public health hazard causing thousands of deaths and injuries each year, with driver fatigue and sleepiness being major causes. A new study has confirmed previous findings that obesity-driven testing strategies identify commercial truck drivers with a high likelihood of obstructive sleep apnea (OSA) and suggests that mandating OSA screenings could reduce the risk of truck crashes.
OSA is a syndrome characterized by sleep-disordered breathing, resulting in excessive daytime sleepiness, sleep attacks, psychomotor deficits, and disrupted nighttime sleep. It increases the risk of motor vehicle accidents, and is common among truck drivers. Approximately 2.4 to 3.9 million licensed commercial drivers in the U.S. are expected to have OSA. In addition to being unrecognized or unreported by drivers, OSA often remains undiagnosed by many primary care clinicians despite the fact that OSA increases the risks of hypertension,
diabetes mellitus, and heart disease.
Philip Parks, MD, MPH, medical director of Lifespan's employee health and occupational services, is the study's lead author. He worked with researchers at the Cambridge Health Alliance on the study published in the March 2009 edition of the Journal of Occupational and Environmental Medicine. Parks says, "It is well-known that obesity, a leading risk factor for obstructive sleep apnea, is on the rise in the United States. Truck drivers with sleep apnea have up to a 7-fold increased risk of being involved in a motor vehicle crash."
Over the 15-month study period, 456 commercial drivers were examined from over 50 different employers. Seventy-eight (17%) met the screening criteria for suspect OSA. These drivers were older and more obese, and had a higher average blood pressure. Of the 53 drivers who were referred for sleep studies, 33 did not comply with the referral and were lost to follow-up. The remaining 20 were all confirmed to have OSA, but after diagnosis, only one of these 20 drivers with confirmed OSA complied with treatment recommendations.
Parks also notes, "Although it is not surprising, it is concerning that we found that drivers with sleep apnea frequently minimize or underreport symptoms such as snoring and daytime sleepiness. In our study, the majority of truck drivers did not follow through on physician recommendations for sleep studies and sleep apnea treatment." He continues, "As a result, it is possible that many of the 14 million truck drivers on American road have undiagnosed or untreated sleep apnea."
Stefanos N. Kales, MD, MPH, Medical Director of Employee and Industrial Medicine at Cambridge Health Alliance, is the study's senior author. Kales says, "It is very likely that most of the drivers who did not comply with sleep studies or sleep apnea treatment sought medical certification from examiners who do not screen for sleep apnea and are driving with untreated or inadequately treated sleep apnea."
The study, published by the Journal of Occupational and Environmental Medicine, has significant policy ramifications, as the Federal Motor Carrier Safety Administration is currently deliberating recommendations to require sleep apnea screening for all obese drivers based on body mass index or "BMI" (BMI is calculated based on height and weight). The Administration requires medical certification of licensed commercial drivers at least every two years. These occupational medicine exams present a unique opportunity for detecting OSA as part of determining a driver's safety behind the wheel.
"OSA screenings of truck drivers will be ineffective unless they are federally mandated or required by employers," said Kales. The study's authors also support the prohibition of "doctor shopping." Dr. Kales added, "Such action would prohibit drivers diagnosed with a serious disorder that might limit driving or require treatment to seek out more lenient or less rigorous medical examiners."


 
A Sleep Study May be Your Best Investment for Long-Term Health

A sleep study gathers information to help your doctor detect problems such as obstructive sleep apnea (OSA).


American Academy of Sleep Medicine
AASM | 10/09/2008

Current economic conditions in the U.S. are forcing many consumers to cut back on health-care expenses. Yet sleep experts advise that the cost of a sleep study is a sound investment for millions of people who suffer from a sleep disorder.
The Centers for Disease Control and Prevention reports that about 15 million adults in the U.S. did not receive needed medical care in 2005 because they could not afford it. In July the National Association of Insurance Commissioners conducted a national survey. Results show that 22 percent of people have reduced the number of times they visit the doctor because of current economic conditions.
In such a challenging economy, should your sleep needs be a priority? Absolutely, said American Academy of Sleep Medicine President Dr. Mary Susan Esther.
“Sleep is one of the cornerstones of good health,” she said. “It affects everything from your weight and blood pressure to your energy and mood. If you have been struggling with an ongoing sleep problem, then a sleep study may be just what you need. It could be the key that unlocks the door to a dramatic improvement in your health and a better quality of life for you.”

The Need
The National Center on Sleep Disorders Research estimates that 50 million to 70 million Americans suffer from sleep problems. These problems affect men and women, children and the elderly, and people of all ethnicities.
The American Academy of Sleep Medicine reports that there are more than 80 specific sleep disorders. These include insomnia, obstructive sleep apnea, restless legs syndrome and snoring.
Yet the majority of people with a sleep disorder remain undiagnosed and untreated. Often people who have a sleep disorder fail to recognize that something is wrong.
“People are notorious for underestimating how sleepy they are,” said AASM spokesperson Dr. David Kuhlmann. “People assume that their disrupted sleep and level of sleepiness when awake is normal for their age.”
Symptoms of some sleep disorders also can go unnoticed. For example loud snoring and gasping for breath during sleep are two warning signs for sleep apnea. But you may be unaware of these symptoms if you live or sleep alone.
As a result, millions of people go through each day wondering why they can’t stay awake. Others go to bed each night wondering why they can’t sleep. The answers to these questions often can be found by a sleep study.
 
The Benefits
Research shows that there are numerous benefits to detecting a sleep disorder with a sleep study. The study pinpoints the nature and cause of your sleep problem. This provides the foundation for an effective treatment plan.
Treating a sleep disorder promotes health and well-being.   In the long run it also can save you money. These are some of the benefits of detecting and treating a sleep disorder:
  • Improved Health
Research has linked sleep disorders to many other health problems. These include heart disease, high blood pressure, stroke, diabetes and obesity. A study in the August 1 issue of the journal Sleep even shows that people with severe, untreated sleep apnea have five times the risk of dying from a heart problem. Effective treatment of a sleep disorder can reduce the risk and severity of other related health problems.
  • Reduced Spending

Studies have linked undetected and untreated sleep disorders to an increase in health-care utilization and spending. You are likely to make more visits to the doctor’s office each year. You also are likely to spend more money on your health care. Expenses may include testing, medications and hospitalization. Research shows that effective treatment of a sleep disorder can reduce your health-care spending. Compared to the high cost of remaining untreated, treating most sleep disorders is relatively inexpensive.

  • Greater Productivity
Studies have linked sleep disorders to lower productivity and more absences at work. A severe sleep disorder even may prevent you from being able to stay employed. Effective treatment of a sleep disorder can enable you to improve your job performance.
  • Better Safety
Research has linked sleep disorders to an increased risk of work-related injuries and motor-vehicle accidents. Effective treatment of a sleep disorder promotes your safety at work and on the road.
  • Improved Quality of Life
Sleep disorders can take a severe toll on your personal well-being. Effective treatment of a sleep disorder can lead to improvements in your mood, attitude, energy, memory and overall outlook on life. An untreated sleep disorder also can put a strain on your relationships. It may disturb the sleep of your spouse, bedpartner or other loved ones. Treatment can contribute to a more harmonious household.
 
The Study
 
A sleep study requires you to spend the night in a bedroom at a sleep disorders center. Many of these centers are located at a hospital or university. Others are “freestanding,” private practices.
A sleep study gathers the information that will help your doctor solve the riddle of your sleep problem. During the night sensors and electrodes record enough data to fill a textbook. Recorded signals include brain waves; heart activity; oxygen levels; breathing effort; airflow; and eye, chin, arm and leg movements.
A small microphone picks up your snoring or any other sounds you make. A video camera records your sleep to document any unusual behavior.
During the night a technician monitors the equipment to ensure that it functions properly. After the study all of the data is analyzed. According to AASM spokesperson Dr. Ron Kramer, the results of your study should be reviewed by a doctor who is board certified in sleep medicine.
“Patients will get the best care when their sleep study is overseen and interpreted by a board-certified sleep specialist,” he said.
 
The Coverage
Insurance coverage for sleep studies has expanded since Blue Shield of California began reimbursing patients for sleep services in 1975. Today most health insurance plans include coverage for sleep-medicine services.
“Health insurances generally pay for sleep studies in their entirety,” said Kuhlmann. He is the medical director of sleep medicine at Bothwell Regional Health Center in Sedalia, Mo.
Some insurance providers require that a sleep study be performed at an AASM-accredited sleep center. AASM accreditation ensures that a sleep-medicine provider meets the highest standards of quality patient care.
An alternative to the overnight sleep study is home sleep testing. It was endorsed by the AASM in December 2007. It also was approved by the Centers for Medicare and Medicaid Services last March.
As a result of these decisions many insurance providers have begun to cover home sleep tests. Coverage restrictions may vary by region of the country.
The advantages of a home sleep test are its convenience and its lower cost. But these “limited-channel” devices have a more limited usefulness. They record just a few signals and are only able to detect obstructive sleep apnea.   
“Portable monitoring should not be performed when patients have significant medical comorbidities or when sleeping disorders other than obstructive sleep apnea are suspected,” said Kuhlmann.
 
The Discussion
Not everyone with a sleep problem needs a sleep study. For example, a doctor usually can determine the cause of insomnia without needing data from a sleep study.
Your doctor can decide if a sleep study is right for you. But your doctor is unlikely to refer you for a sleep study unless you first make him or her aware of your sleep problem. You should discuss your sleep the next time you visit your doctor. 

 
National Sleep Foundation Alert

Healthcare Providers Urged to Address the Link between Sleep Apnea and Type 2 Diabetes

The International Diabetes Federation (IDF) Task Force on Epidemiology and Prevention has published a consensus statement in the journal Diabetes Research and Clinical Practice on the close link between type 2 diabetes and obstructive sleep apnea (OSA). According to the statement:

  • Up to 40 percent of people with OSA will have diabetes.
  • Among diabetes patients, the prevalence of some form of sleep disordered breathing (e.g., snoring) may be as high as 58 percent.
  • The link between OSA and diabetes may be independent of overweight/obese status.

In addition to supporting the need for further research into the links between OSA and diabetes, the task force strongly recommends that health professionals adopt clinical practices to ensure that a patient presenting with one condition is considered for the other.

  • Read the abstract.
Date: 6/16/2008

 
National Sleep Foundation Alert

Even Mild Sleep Apnea Increases Risk of Heart Disease

Even patients with mild obstructive sleep apnea (OSA) experience symptoms that increase their risk of cardiovascular disease, according to a study in the journal American Journal of Respiratory and Critical Care Medicine. Researchers at the Oxford Center for Respiratory Medicine examined 64 patients with minimally symptomatic OSA and 15 control subjects without OSA. They found that patients with mild OSA experienced increased stiffness of the arteries and impaired vascular function, putting them at increased risk of cardiovascular disease. "It was previously known that people with OSA severe enough to affect their daytime alertness and manifest in other ways are at increased risk of cardiovascular disease, but this finding suggests that many more people, some of whom may be completely unaware that they even have OSA, are at risk than previously thought," the study's author, Dr. Malcolm Kohler, said in a press release from the American Thoracic Society. If you suspect you may have sleep apnea, see your doctor or call your medical insurance provider to find out if a referral is needed for a visit to a sleep center.

  • Read the abstract.
Date: 10/24/2008

 

Sleep Apnea May Spur Erectile Dysfunction

ED Drug Cialis Helped but Didn't Overcome Problem in Lab Tests on Mice

By Miranda Hitti
WebMD Health News

Reviewed By Louise Chang, MD

Latest Mens Health News

Sept. 12, 2008 -- sleep apnea may make erectile dysfunction more likely, and the erectile dysfunction drug Cialis may ease but not erase that problem, new research shows.

Those findings come from lab tests on mice, but the researchers say that erectile dysfunction (ED) is common among men with obstructive sleep apnea, a condition in which breathing stops several times per night.

In the new study, male mice showed less sexual activity within a week of being exposed to brief but chronic bouts of oxygen deprivation during sleep. That includes attempts to mate with female mice and spontaneous erections.

The researchers, who included the University of Louisville's Galia Soukhova-O'Hare, ground up Cialis pills and mixed them into peanut butter for the male mice. The mice became more sexually active, but not quite as active as they had been before the study started.

How were sleep apnea and ED linked? Testosterone wasn't the problem; testosterone levels were unaffected by sleep apnea. And there weren't any problems with the mice's anatomy, either.

But the mice did have lower levels of an enzyme needed to make nitric oxide during the experiment, and they may have needed nitric oxide to help with blood flow for erections.

The researchers stop short of recommending ED drugs for men with sleep apnea, and they also note that using a continuous positive airway pressure (CPAP) machine to treat sleep apnea can help with erectile dysfunction.

The findings appear in the Sept. 15 edition of the American Journal of Respiratory and Critical Care Medicine.

SOURCES: Soukhova-O'Hare, G. American Journal of Respiratory and Critical Care Medicine, Sept. 15, 2008; vol 178: pp 644-650. News release, American Thoracic Society.


 

Heavy Snoring Could Indicate Narrowing of Arteries

According to a study in the journal Sleep, heavy snoring could significantly increase the risk of carotid atherosclerosis, or plaque buildup within the main arteries of the neck, which can lead to stroke. Researchers examined 110 volunteers, who were categorized into three different groups of snorers: mild, moderate and heavy. Using polysomnography and other tests to measure snoring and plaque buildup, they found that the prevalence of carotid atherosclerosis was 20 percent with mild snoring, 32 percent with moderate snoring and 64 percent with heavy snoring. The risk of buildup was found to be independent of other risk factors, such as the severity of obstructive sleep apnea.

Date: 9/15/2008

 
National Transportation Safety Board Makes Recommendations on Fatigue Management


The National Transportation Safety Board (NTSB) concluded on Sept. 16 that fatigue was the probable cause of a 2005 semi rollover accident in western Wisconsin which led to a motorcoach crash with the overturned truck.  Five people were killed and 35 injured. 

As part of its conclusions, NTSB recommended that the federal government take steps to address the problem of fatigue on America's highways. One recommendation requests that the Federal Motor Carrier Safety Administration continually assess the effectiveness of the fatigue management plans implemented by motor carriers, including their ability to improve sleep and alertness.

The National Sleep Foundation has been involved in the debate over "Hours of Service" regulations for commercial drivers, arguing that the rules should be updated to reflect current scientific understanding of fatigue and circadian rhythms.

Date: 9/22/2008


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